Endocrine Abstracts

Introduction: Interleukin (IL)-6 can activate signal transducer and activator of transcription (STAT)3-dependent signaling similar to leptin in neurons. Here we demonstrate that central application of IL-6 suppresses feeding and improves glucose tolerance in mice. Furthermore, we found that central IL-6 trans-signaling is enhanced in obese mice to improve anorexigenic and glucoregulatory effects of IL-6.Methods/design: Glucose tolerance and insulin sensi...

In light of the ever-increasing incidences of obesity and T2DM, development of novel therapeutic or preventative measures to combat these epidemics is of utmost importance. Identification of a causal relationship between an altered maternal metabolic homeostasis and an increased propensity for the unborn child to develop metabolic disorders throughout lifetime has shifted considerable amount of attention towards understanding the underlying cellular and molecular alterations. ...